We are interested in the mechanisms that dictate the biogenesis, trafficking, and function of endolysosomes and mitochondria. These studies are relevant to diseases stemming from lysosomal and mitochondrial dysfunction, aging, and cancer.

Related papers:  Venkatachalam et al., Cell, 2008; Wong et al., Current Biology, 2012; Venkatachalam et al., Autophagy, 2013; Venkatachalam et al., Cell Calcium, 2014; Wong et al., Cell Host & Microbe, 2017; Jung et al., EMBO Reports, 2019; Jung et al., iScience, 2021

We use a multi-tiered approach to study the regulation of neuronal function and bioenergetics. Our goal is to glean fundamental insights into the functioning of the nervous system, and develop strategies to ameliorate the pathological consequences of neurodevelopment and neurodegenerative diseases.

Related papers: Venkatachalam et al, Cell, 2008; Wong et al., Cell Reports, 2015; Wong et al, Neuron, 2014; Wong and Venkatachalam, Human Molecular Genetics, 2019; Wong and Karagas et al., PNAS, 2021; Karagas et al, BioRxiV, 2021