Endolysosomes play key roles in many biological pathways. We take a molecular genetic approach to understand the function of various proteins involved in the biogenesis, trafficking, and function of these fascinating organelles. In addition to the obvious relevance to lysosomal storage diseases, these studies are also aimed at uncovering insights into immunity, cancer and many neurodegenerative diseases.

Related papers:  Venkatachalam et al., Cell, 2008; Wong et al., Current Biology, 2012; Venkatachalam et al., Autophagy, 2013; Venkatachalam et al., Cell Calcium, 2014; Wong et al., Cell Reports, 2015; Wong et al., Cell Host & Microbe, Wong et al., Cell Host and Microbe, 2017; Jung et al., EMBO Reports, 2019 

The development and maintenance of synaptic connections are critical for the efficacy of neuronal information transfer. We use a multi-tiered approach to study genes required for synaptic development, neurotransmission, and the prevention of neurodegeneration. Our goal is to glean fundamental insights into the functioning of the nervous system, and develop strategies to ameliorate the pathological consequences of neurological diseases.

Related papers: Venkatachalam et al, Cell, 2008; Wong et al, Neuron, 2014; Wong and Venkatachalam, Human Molecular Genetics, 2019