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Venkatachalam et al., Autophagy, 2013
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Wong et al., Neuron, 2014
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Wong et al., Cell Host and Microbe, 2017
2022

41. Karagas, N.E., Gupta, R., Rastegari, E., Tan, K.L., Hang Leung, H., Bellen, H.J., Venkatachalam, K.*, and Wong, CO.* (2022) Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila model of ALS. Journal of Neuroscience. 19;42(42):8019-8037. * Corresponding authors. PDF


40. Venkatachalam, K. (2022) Regulation of Aging and Longevity by Ion Channels and Transporters. Cells. 2022, 11, 1180. https://doi.org/10.3390/cells11071180. PDF

39. Martelli, F., Hernandes, N.H., Zuo, Z., Wang, J., Wong, CO., Karagas, N.E., Roessner, U., Rupasinghe, T., Robin, C., Venkatachalam, K., Perry, T., Batterham, P., and Bellen H.J. (2022) Low Doses of the Organic Insecticide Spinosad Trigger Lysosomal Defects, Elevated ROS, Lipid Dysregulation, and Neurodegeneration in Flies. eLife 2022;11:e73812. DOI: 10.7554/eLife.73812. PDF
2021

38. Jung, J., Liao, H., Coker, S.A., Liang, H., Hancock, J.F., Denicourt, C., and Venkatachalam, K. (2021) p53 Mitigates the Effects of Oncogenic HRAS in Urothelial Cells via the Repression of MCOLN1. iScience. 24:10271. PDF

​37. Wong, CO.*, Karagas, N.E.*, Jung, J., Wang, Q., Rousseau, M. A., Chao, Y., Insolera, R., Soppina, P., Collins, C.A., Zhou, Y., Hancock, J.F., Zhu, M.X., and Venkatachalam, K. (2021) Regulation of Longevity by Depolarization-Induced Activation of PLC(beta)–IP3R Signaling in Neurons. Proceedings of the National Academy of Sciences (USA). 118(16): e2004253118. PDF
​* Co-first authors
​2020

36. Martelli, F., Zhongyuan, Z., Wang, J., Wong, CO., Karagas, N.E., Roessner, U., Rupasinghe, T., Venkatachalam, K.,  Perry, T., Bellen, H.J. and Batterham, P. (2020) Low Doses of the Neonicotinoid Insecticide Imidacloprid Induce ROS Triggering Neurologic and Metabolic Impairments in Drosophila. Proceedings of the National Academy of Sciences (USA). 117(41): 25840-25850. PDF

35.    Karagas, N.E., Rousseau, M.A, and Venkatachalam, K. (2020) TRPML Family of Endolysosomal Channels: Concepts and Methods. Ion and Molecule Transport in Lysosomes (1st Edition). Chapter 4. PDF

34.    Gripp, K.W., Schill, L., Schoyer, L., Stronach, B., Bennett, A.M., Blaser, S., Brown, A., Burdine, R., Burkitt-Wright, E., Castel, P., Darilek, S., Dias, A., Dyer, T., Ellis, M., Erickson, G., Gelb, B.D., Green, T., Gross, A., Ho, A., Holder, J.L. Jr., Inoue, S.I., Jelin, A.C., Kennedy, A., Klein, R., Kontaridis, M.I., Magoulas, P., McConnell, D.B., McCormick, F., Neel, B.G., Prada, C.E., Rauen, K.A., Roberts, A., Rodriguez-Viciana, P., Rosen, N., Rumbaugh, G., Sablina, A., Solman, M., Tartaglia, M., Thomas, A., Timmer, W.C., Venkatachalam, K., Walsh, K.S., Wolters, P.L., Yi, J.S., Zenker, M.,and Ratner, N. (2020) The sixth international RASopathies symposium: Precision medicine—From promise to practice. American Journal of Medical Genetics A. 182(3): 597-606. PDF 
2019

33.    Jung, J., and Venkatachalam, K. (2019) TRPing the homeostatic alarm - Melanoma Cells are selectively vulnerable to TRPML1 deletion. Cell Calcium 84:10282. PDF

32.    Jung, J., and Venkatachalam, K. (2019) TRPML1 and Ras-driven cancers - exploring a link with great therapeutic potential. Channels (Austin) 13(1):374-381. PDF

31.    Karagas, N.E., and Venkatachalam, K. (2019) Roles for the endoplasmic reticulum in neuronal calcium homeostasis. Cells 8(10):e1232. PDF

30.    Wong, CO., and Venkatachalam, K. (2019) Motor neurons from ALS patients with mutations in C9ORF72 and SOD1 exhibit distinct transcriptional landscapes. Human Molecular Genetics 28(16):2799-2810. PDF

29.    Jung, J., Cho, K-J., Naji, A.K., Clemons, K.N., Wong, CO., Villanueva, M., Gregory, S., Karagas, N.E., Tan, L., Liang, H., Rousseau, M.A., Tomasevich, K.M., Sikora, A.G., Levental, I., van der Hoeven, D., Zhou, Y., Hancock, J.F. and Venkatachalam, K. (2019) HRAS-driven cancer cells are vulnerable to TRPML1 inhibition. EMBO Reports e46685. PDF
[Accompanying this article was the following 'News and Views': Schwartz, D.M. and Muallem, S. (2019) Oncogenes calling on a lysosomal Ca2+ channel. EMBO Reports e7973. PDF]
2017
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28.    Wong, CO., Gregory, S., Hu, H., Chao, Y., Sepúlveda, VE., He, Y., Li-Kroeger D., Goldman W.E., Bellen, H.J., and Venkatachalam, K. (2017) Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages. Cell Host and Microbe 21(6):719-730. ​(Cover Article) PDF

27.    Venkatachalam, K. (2017) VGLUT Soothes the Sour Syanpse. The Journal of Physiology 593.3: 615-616. ​PDF


2016

26.    Kliosnky, D.J. et al. (2016) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition). Autophagy 12:1-222. PDF

2015

25.    Wong, CO., Palmieri, M., Li, J., Akhmedov, D., Chao, Y., Broadhead, G.T., Zhu, M.X., Berdeaux, R., Collins, C.A., Sardiello, M., and Venkatachalam, K. (2015) Diminished MTORC1-Dependent JNK-Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Cell Reports 12: 2009-2020. PDF

24.     Zhou, Y., Wong, CO., Cho, K-J., van der Hoeven, D., Liang, H., Thakur, D.P., Luo, J., Babic, M., Zinsmaier, K.E., Zhu, M.X., Hu, H., Venkatachalam, K., and Hancock, J.F. (2015) Membrane Potential Modulates Plasma Membrane Phospholipid Dynamics and K-Ras Signaling. Science 349(6250): 873-876. PDF

[Accompanying this article was the following commentary: Accardi, A. (2015) Lipids Link Ion Channels and Cancer. Science
349(6250): 789-790. PDF]

23.
    Venkatachalam, K.*, Wong, CO., and Zhu, M.X.* (2015) The Role of TRPMLs in Endolysosomal Trafficking and Function. Cell Calcium 58: 48-56.(*, corresponding authors) PDF


22.    Tian, X., Gala, U., Zhang, Y., Shang, W., Jaiswal, S.N., Ronza, A.D., Jaiswal, M., Yamamoto, S., Sandoval, H., Duraine, L., Sardiello, M., Sillitoe, R.V., Venkatachalam, K., Fan, H., Bellen, H.J., and Tong, C. (2015) A Voltage Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and is Required for Neuronal Homeostasis. PLoS Biology
13(3): e1002103. PDF

21. 
Venkatachalam, K.* and Kiselyov, K.* (2015) TRPML1-Dependent Processes as Therapeutic Targets. TRP Channels as Therapeutic targets 469-482. (*, corresponding authors)
2014

20.    Wong, CO., Chen, K., Lin, YQ., Chao, Y., Duraine, L., Lu, Z., Yoon, WH., Sullivan, J.M., Broadhead, G.T., Sumner, C.J. Lloyd, T.E., Macleod, G.T., Bellen, H.J., and Venkatachalam, K. (2014) A TRPV Channel in Drosophila Motor Neurons Regulates Presynaptic Resting Ca2+ Levels, Synapse Growth, and Synaptic Transmission. Neuron 84: 764-777. (Cover Article) PDF


[Accompanying this article was the following preview: Imler, E. and Zinsmaier, K.E. (2014) TRPV1 Channels: Not So Inactive on the ER. Neuron 84: 659-661. PDF]

19.     Venkatachalam, K.*, Luo, J., and Montell, C.* (2014) Evolutionarily Conserved, Multitasking TRP Channels—Lessons From Worms and Flies. Handbook of Experimental Pharmacology, Edition on "Mammalian Transient Receptor Potential (TRP) Channels" 223: 937-962. (*, corresponding authors) PDF

18.     Wang, S., Tan, K.L., Agosto, M.A., Xiong, B., Yamamoto, S., Sandoval, H., Jaiswal, M., Bayat, V., Zhang, K., Charng, W-L., David, G., Duraine, L., Venkatachalam, K., Wensel, T.G., and Bellen, H.J. (2014) The Retromer Complex is Required for Rhodopsin Recycling and Its Loss Leads to Photoreceptor Degeneration. PLoS Biology 12(4): e1001847. PDF

17.     Feng, X., Huang, Y., Lu, Y., Xiong, J., Wong, CO., Yang, P., Xia, J., Chen, D., Du, G., Venkatachalam, K., Xia, X. and Zhu, MX. (2013) Drosophila TRPML Forms PI(3,5)P2-Activated Cation Channels in Both Endolysosomes and Plasma Membrane. Journal of Biological Chemistry 289: 4262-4272. PDF

2013

16.    Venkatachalam, K.*, Wong, CO., and Montell, C.* (2013) Feast or Famine: Role of TRPML in Preventing Cellular Amino Acid Starvation. Autophagy 9: 98-100. (Cover Article)(*, corresponding authors) PDF

2012

15.   Wong, CO., Li, R., Montell, C. and Venkatachalam, K. (2012) Drosophila TRPML is Required For TORC1 Activation. Current Biology 22: 1616-1621. PDF

2010

14.    Venkatachalam, K., Wasserman, D., Wang, X., Li, R., Mills, E., Elsaesser, R., Li, H-S., and Montell, C. (2010) Dependence on a Retinophilin/Myosin Complex For Stability of PKC and INAD and Termination of Phototransduction. Journal of Neuroscience 30: 11337-11345. PDF

2008

13.    Venkatachalam, K., Long, A., Elsaesser, R., Nikolaeva, D., Broadie, K., and Montell, C. (2008) Motor Deficit in a Drosophila Model of Mucolipidosis Type IV Due to Defective Clearance of Apoptotic Cells. Cell 135: 838-851. PDF

2007

12.    Venkatachalam, K., and Montell, C. (2007) TRP Channels. Annual Reviews Biochemistry 76: 387-417. PDF

11.    Kalra, D., Elsaesser, R., Gu, Y., and Venkatachalam, K.* (2007) Transducin in Rod Photoreceptors - Translocated When Not Terminated. Journal of Neuroscience 27: 6349-6351. (*, Corresponding author) PDF

10.    Soboloff, J., Spassova, M., Hewavitharana, T., He, L-P, Luncsford, P., Xu, W., Venkatachalam, K., van Rossum, D., Patterson, R.L., and Gill, D.L. (2007) TRPC Channels: Integrators of Multiple Cellular Signals. Handbook of Experimental Pharmacology 179: 575-591. PDF

2006

9.    Venkatachalam, K., Hofmann, T., and Montell, C. (2006) Lysosomal Localization of TRPML3 Regulated by Interactions with TRPML2 and Mucolipidosis-associated Protein TRPML1. Journal of Biological Chemistry 281: 17517-17527. PDF

2004

8.    Spassova, M.A., Soboloff, J., He, L-P., Hewavitharana, T., Xu, W., Venkatachalam, K., van Rossum, D.B., Patterson, R.L., and Gill, D.L. (2004) Calcium Entry Mediated by SOCs and TRP Channels: Variations and Enigma. Biochimica et Biophysica Acta 1742: 9-20. PDF

7.    Venkatachalam, K., Zheng, F., and Gill D.L. (2004) Control of TRPC and Store-Operated Channels by Protein Kinase C. Novartis Foundation Symposium 258: 172-185; Discussion 185-188, 263-266.

2003

6.    Venkatachalam, K., Zheng, F., and Gill, D.L. (2003) Regulation of TRPC Channel Function by Diacylglycerol and Protein Kinase C. Journal of Biological Chemistry 278: 29031-29040. PDF

5.    Ma, H-T., Venkatachalam, K.*, Rys-Sikora, K.E., He, L-P., Zheng, F., and Gill, D.L. (2003) Modification of Phospholipase C-g-Induced Ca2+ Signal-generation by 2-Amino-ethoxydiphenyl Borate. Biochemical Journal 376: 667-676. (*- Joint First Author) PDF

2002

4.    Venkatachalam, K., van Rossum, D.B., Patterson, R.L., Ma, H-T., and Gill, D.L. (2002) The Cellular and Molecular Basis of Store-Operated Calcium Entry. Nature Cell Biology 4: E263-E272. PDF

3.    Ma, H-T., Venkatachalam, K., Parys, J.B., and Gill D.L. (2002) Modification of Store-operated Channel-coupling and InsP3 Receptor-function by 2-Aminoethoxydiphenylborate in DT40 Lymphocytes. Journal of Biological Chemistry 277: 6915-6922. PDF

2001

2.    Venkatachalam, K., Ma, H-T., Ford, D.L., and Gill, D.L. (2001) Expression of Functional Receptor-Coupled TRPC3 Channels in DT40 Triple InsP3 Receptor-Knockout Cells. Journal of Biological Chemistry 276: 33980-33985. (Featured in Faculty of 1000) PDF

1.    Ma, H-T., Venkatachalam, K.*, Li, H-S., Montell, C., Kurosaki, T., Patterson, R.L., and Gill, D.L. (2001) Assessment of the Role of the Inositol 1,4,5-Trisphosphate Receptor in the Activation of Transient Receptor Potential Channels and Store-Operated Ca2+ Entry Channels. Journal of Biological Chemistry 276: 18888-18896. (*- Joint First Author) PDF

 



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